home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9408c.zip
/
M9480587.TXT
< prev
next >
Wrap
Text File
|
1994-08-20
|
2KB
|
41 lines
Document 0587
DOCN M9480587
TI Metabolism and mechanism of antiretroviral action of purine and
pyrimidine derivatives.
DT 9410
AU Balzarini J; Rega Institute for Medical Research, Katholieke
Universiteit; Leuven, Belgium.
SO Pharm World Sci. 1994 Apr 15;16(2):113-26. Unique Identifier : AIDSLINE
MED/94305498
AB Unlike herpes viruses, human immunodeficiency virus and other
retroviruses do not encode specific enzymes required for the metabolism
of the purine or pyrimidine nucleotides to their corresponding
5'-triphosphates. Therefore, 2',3'-dideoxynucleosides and acyclic
nucleoside phosphonates must be phosphorylated and metabolized by host
cell kinases and other enzymes of purine and/or pyrimidine metabolism.
Different animal species (or even different cell types within one animal
species) may differ in the efficiency of conversion of these drugs to
their antivirally active metabolite(s). Three 2',3'-dideoxynucleosides
are officially licensed for clinical use [i.e., zidovudine
(3'-azido-2',3'-dideoxythymidine, AZT), didanosine
(2',3'-dideoxyinosine, DDI) and zalcitabine (2',3'-dideoxycytidine,
DDC)]. A number of other 2',3'-dideoxynucleoside analogues [among them
stavudine (2',3'-didehydro-2',3'-dideoxythymidine, D4T),
2',3'-dideoxy-3'-thiacytidine (3TC),
2',3'-dideoxy-5-fluoro-3'-thiacytidine (FTC) and the acyclic nucleoside
phosphonate 9-(2-phosphonylmethoxyethyl)adenine (PMEA)] are currently
under clinical investigation and are candidate compounds for eventual
licensing as anti-AIDS drugs. The metabolic pathways, antimetabolic
effects and mechanism of antiviral action of these nucleoside analogues
will be discussed.
DE Animal Antiviral Agents/*PHARMACOLOGY Dideoxyadenosine/PHARMACOLOGY
Dideoxynucleosides/PHARMACOLOGY Human Purines/*PHARMACOLOGY
Pyrimidines/*PHARMACOLOGY Retroviridae/*DRUG EFFECTS
Stavudine/PHARMACOLOGY Thymidine/ANALOGS & DERIVATIVES/PHARMACOLOGY
Zalcitabine/ANALOGS & DERIVATIVES/PHARMACOLOGY Zidovudine/PHARMACOLOGY
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).